My Gmail gets automatically sorted by the labels. Settings -> Inbox Type: Priority Inbox (with 4 slots: Unread, Budgets, Work and Everything else).
E-mails sent to or from my @gearnoodle.com accounts will automatically get labels Work and Gearnoodle.
I use the setting that there are no e-mail chains. All mail are individual e-mails, either sent by me to someone else or something someone else has sent to me. That's because I used to loose my e-mail chains too easily if they didn't contain any unread messages, Gmail didn't seem to sort them to top even if the latest message of the chain is sent just seconds ago. Don't know if the situation has changed.